Lurasidone: Uses – Side Effects – Warnings


Lurasidone is a prescription medication that belongs to a class of drugs known as atypical antipsychotics. It is primarily used to treat schizophrenia and bipolar depression in adults. Lurasidone works by helping to restore the balance of certain chemicals in the brain, which can alleviate symptoms associated with these mental health conditions.

In addition to treating schizophrenia and bipolar depression, lurasidone may also be prescribed off-label for other conditions such as major depressive disorder or certain behavioral issues in children and adolescents.


Lurasidone has been found to be effective in managing symptoms of schizophrenia and bipolar depression. It can help reduce hallucinations, delusions, and other psychotic symptoms in individuals with schizophrenia. Additionally, lurasidone can stabilize mood and provide relief from depressive episodes associated with bipolar depression.

For those suffering from major depressive disorder, lurasidone may offer potential benefits as an adjunct therapy when traditional antidepressants have been ineffective. In children and adolescents, lurasidone may help manage certain behavioral issues, but its use in this group is subject to caution due to potentially severe side effects.

Side Effects

Like any medication, lurasidone may cause side effects. These can vary from person to person, and it is important to discuss any concerns or bothersome symptoms with a healthcare professional. Common side effects include:

  • Drowsiness
  • Nausea
  • Vomiting
  • Headache
  • Weight gain
  • Restlessness
  • Insomnia
  • Decreased libido

Serious side effects are rare but can occur. They include:

  • Severe allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing)
  • High fever, increased sweating, muscle stiffness, and fast or uneven heartbeats
  • Trouble swallowing
  • Unusual urges or compulsive behaviors (such as gambling, binge eating, or uncontrollable shopping)
  • Worsening depression or suicidal thoughts

It is crucial to seek immediate medical attention if any severe or unusual side effects are experienced.


Prior to starting treatment with lurasidone, patients and healthcare providers should carefully consider the potential risks and benefits of the medication. It is important to disclose all current medications, medical history, and any other relevant information to the healthcare provider to ensure the safe and effective use of lurasidone.

Lurasidone may interact with certain medications, such as other antipsychotics, antidepressants, and certain antibiotics. These interactions can increase the risk of side effects or affect the effectiveness of either medication. It is essential to inform the healthcare provider of all current medications to avoid potential drug interactions.

Additionally, lurasidone can cause drowsiness and impair judgment, coordination, and motor skills. It is crucial to avoid driving or operating machinery until the impact of lurasidone on cognitive and motor function is understood.

Special caution must be exercised when lurasidone is used in older adults, as they may be more susceptible to certain side effects, such as dizziness and neurological changes. Moreover, lurasidone may increase the risk of falls in elderly individuals.


Can lurasidone be used to treat other mental health conditions?

Lurasidone is primarily indicated for schizophrenia and bipolar depression, but it may be prescribed off-label for other conditions. Discuss your specific needs with a healthcare provider for personalized advice.

How long does it take for lurasidone to start working?

Lurasidone generally takes several weeks to reach its full therapeutic effect. It is crucial to follow the prescribed dosage and consult with a healthcare provider to monitor the treatment’s progress.

Can lurasidone cause weight gain?

Weight gain is a potential side effect of lurasidone. If weight gain becomes a concern, consulting with a healthcare provider can help manage this effect.

Can lurasidone be used during pregnancy?

The safety of lurasidone during pregnancy has not been established. It is essential to discuss the potential risks and benefits with a healthcare provider if pregnancy is planned or suspected.

Can lurasidone be used in children and adolescents?

Lurasidone may be used in children and adolescents for certain behavioral issues, but its use is subject to caution and should be carefully monitored by a healthcare professional due to the potential for severe side effects.

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