Otezla: Uses – Side Effects – Warnings

Otezla is a prescription medication used to treat psoriasis and psoriatic arthritis. It contains the active ingredient apremilast and is taken orally. This medicine works as a phosphodiesterase 4 (PDE4) inhibitor, reducing inflammation.


Otezla has been approved for the treatment of adult patients with moderate to severe plaque psoriasis, active psoriatic arthritis, and Behcet’s disease. Psoriasis is an autoimmune skin condition that causes cells to build up rapidly on the surface of the skin, leading to redness, scaling, and itching. Psoriatic arthritis is a type of arthritis that affects some people with psoriasis and causes joint pain, stiffness, and swelling.


Otezla comes with many benefits:

  1. It is an oral medication, which means it can be taken at home.
  2. It has been shown to relieve symptoms of psoriasis and psoriatic arthritis.
  3. It can reduce the frequency and severity of flare-ups.
  4. It can improve the quality of life of patients with these conditions.

Side Effects

Like all medications, Otezla can cause side effects. Side effects can vary from person to person. The most common side effects of Otezla are:

  1. Diarrhea
  2. Nausea
  3. Headache
  4. Upper respiratory tract infection
  5. Upper abdominal pain

It is important to tell your doctor immediately if you experience any side effects while taking Otezla.


Before taking Otezla, it is important to know the following warnings:

  1. Do not take Otezla if you are allergic to apremilast or any of the ingredients in Otezla.
  2. Otezla can cause serious side effects, including depression and suicidal thoughts. If you experience any mood changes, tell your doctor immediately.
  3. Otezla can increase the risk of infection. Tell your doctor if you have any signs of an infection, such as fever, chills, or sweating.
  4. Otezla can increase the risk of serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. If you experience any skin rash, blisters, or peeling, tell your doctor immediately.


How long does it take for Otezla to work?

Otezla can take up to 16 weeks to work fully.

Can Otezla be used during pregnancy?

Otezla is not recommended for use during pregnancy.

Can Otezla be used if I have liver disease?

Otezla can be used in patients with liver disease, but your doctor may need to adjust the dose.

Can Otezla be used with other medications?

Otezla can be used with other medications, but your doctor will need to determine if there are any interactions.

How often do I need to take Otezla?

Otezla is usually taken twice a day, with or without food. Follow your doctor’s instructions on how to take it correctly.

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