Aygestin: Uses – Side Effects – Warnings

Aygestin is a medication that is used to treat abnormal uterine bleeding, amenorrhea (no menstrual periods), and endometriosis. It was initially approved by the FDA in 1957 and is available in its generic form, norethindrone acetate.


Aygestin works by changing the hormonal balance in the body. It is a synthetic progestin, which acts similarly to the natural hormone progesterone, found in the female body. It can be used for the following conditions:

1. Abnormal Uterine Bleeding (AUB): Aygestin is used to treat AUB that is due to hormonal imbalances, such as anovulation (absence of ovulation) or dysfunctional uterine bleeding (DUB). It helps regulate the menstrual cycle and stops abnormal bleeding.

2. Amenorrhea: Aygestin is used to treat amenorrhea, which is the absence of menstrual periods in women of reproductive age who are not pregnant, breastfeeding, or going through menopause.

3. Endometriosis: Aygestin is used to treat endometriosis, a condition that occurs when the tissue that lines the uterus grows outside of the uterus. This growth can cause pain, infertility, and heavy bleeding during periods.


Aygestin can be very beneficial in treating the above conditions. It can help regulate menstrual cycles, reduce abnormal bleeding, relieve pain caused by endometriosis, and improve fertility in women with amenorrhea.

Side Effects

Like any medication, Aygestin can have side effects. The most common side effects include:

1. Nausea
2. Dizziness
3. Headache
4. Acne
5. Breast tenderness
6. Weight gain
7. Irregular periods
8. Mood changes

These side effects are generally mild and go away after a few weeks. However, if they persist or become severe, it is essential to contact a healthcare provider immediately. Some serious side effects of Aygestin include:

1. Blood clots
2. Stroke
3. Heart attack
4. Liver problems
5. Allergic reactions

If you experience any of these symptoms, seek medical attention right away.


Aygestin should not be used in certain circumstances. Women who are pregnant, breastfeeding, or have a history of breast or uterine cancer should not take this medication. Additionally, women with a history of blood clots, stroke, or heart disease should not take Aygestin.

Women who smoke or are over 35 years old and taking Aygestin are at an increased risk of blood clots, stroke, and heart attack. Therefore, discussing your medical history with your healthcare provider before using Aygestin is essential.

One of the most crucial warnings for Aygestin is that it can increase the risk of endometrial cancer. Therefore, women who take this medication for extended periods need to have regular pelvic exams and Pap smears to monitor changes in the endometrial lining.


How long does it take for Aygestin to regulate menstrual cycles?

Aygestin can take several weeks to regulate menstrual cycles. It is essential to take the medication as directed by your healthcare provider.

Is Aygestin addictive?

No, Aygestin is not an addictive medication.

Can Aygestin be taken with other medications?

It is essential to discuss any other medications you are taking with your healthcare provider before taking Aygestin to avoid potential drug interactions.

How long does it take for Aygestin to relieve endometriosis pain?

Aygestin can take several weeks to relieve endometriosis pain. However, the duration can vary depending on the severity of the condition.

Can Aygestin cause weight gain?

Some women report weight gain while taking Aygestin. However, it is not a common side effect, and weight gain can be managed through proper diet and exercise.

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