Compazine: Uses – Side Effects – Warnings

Compazine is a widely used medication prescribed for the treatment of nausea, vomiting, and certain mental health conditions. Compazine contains prochlorperazine, which is classified as a phenothiazine, and is an antipsychotic medication that regulates brain function.

Compazine has been in use since the 1950s and is available in various forms, including orally disintegrating tablets, injections, and suppositories. While the drug has proven effective in treating various conditions, it may cause certain side effects. Therefore, it is crucial for potential users to be aware of the uses, benefits, side effects, and warnings associated with Compazine.


Compazine is primarily used for the treatment of:

  • Nausea and vomiting: Compazine helps in controlling nausea and vomiting in patients suffering from chemotherapy, radiation, or surgery.
  • Mental health conditions: Compazine can also help in managing mental health conditions that cause symptoms such as hallucinations, aggression, anxiety, and psychosis.

It is also used as a sedative for patients undergoing surgical procedures or to manage migraine headaches.


Compazine offers several benefits, including:

  • Effective in managing nausea and vomiting: Compazine reduces symptoms of nausea and vomiting, making it easier for patients to manage their conditions.
  • Improves mental health: Compazine effectively targets and manages mental health conditions that cause symptoms such as hallucinations, aggression, and anxiety.
  • Pain relief: Compazine’s antihistaminic properties help manage migraines associated with pain.

Side Effects

Like any medication, Compazine may cause side effects. Some of the common side effects are:

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Blurred vision
  • Constipation
  • Skin rash or itching
  • Tardive dyskinesia (involuntary movement of the face and mouth)

In rare cases, Compazine can cause serious side effects such as:

  • Neuroleptic malignant syndrome (a severe reaction to antipsychotic medication similar to a heatstroke)
  • Seizures
  • Low blood pressure
  • Jaundice (yellowing of the skin or eyes)

If any of these side effects occur, medical attention should be sought immediately.


Compazine has several warnings that users should be aware of before starting the medication. These warnings include:

  • Avoid operating heavy machinery or doing any work that requires mental alertness while taking Compazine.
  • Precaution is necessary for patients with liver or kidney disease, asthma, heart disease, or a history of seizures.
  • Compazine can increase the risk of falls, especially in elderly patients.
  • Compazine may cause drowsiness, so it is not recommended to consume alcohol while taking the medication.
  • Pregnant women, women who are breastfeeding, and children under the age of two should not take Compazine.


In conclusion, Compazine is an effective medication for managing nausea, vomiting, and certain mental health conditions, in addition to offering several benefits. However, users should be aware of its associated side effects and warnings before starting the medication to minimize risks. It is crucial to consult with a healthcare professional before using Compazine.


How long does it take for Compazine to start working?

Compazine usually takes approximately 30 minutes to start working when administered orally. The onset of Compazine when given through an intramuscular injection or suppository can be seen as early as 15-30 minutes.

How often should I take Compazine?

The dosage and administration of Compazine significantly depend on the condition being treated. A healthcare professional will provide the recommended dosage information, and patients should follow the prescribed instructions.

Can Compazine cause drowsiness?

Yes, Compazine can cause drowsiness. Patients taking Compazine should avoid activities that require mental alertness, such as driving a car or operating machinery.

Can I take Compazine with other medications?

Before taking Compazine, patients should inform their physician of all medications they are taking, including prescription and non-prescription medications.

Can Compazine cause addiction?

Compazine is not known to be addictive. However, extended use of the medication may result in physical and mental dependence. Patients should follow their physician’s recommended dosage schedule and avoid misuse of the medication.

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