Repatha, or evolocumab, is a medication used to treat high levels of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol is commonly known as “bad” cholesterol and can increase the risk of heart disease, stroke, and other cardiovascular problems. Repatha works by inhibiting a protein in the liver that reduces the breakdown of LDL cholesterol. This medication is usually prescribed to people who cannot lower their cholesterol levels through diet and exercise alone.
Uses
Repatha is primarily used to lower LDL cholesterol levels in people with high cholesterol who are at risk of cardiovascular disease. The medication is usually prescribed to people with hypercholesterolemia, familial hypercholesterolemia, or people who have had a heart attack or stroke. Repatha has also been used in clinical trials to treat people with homozygous familial hypercholesterolemia, a rare genetic condition that causes very high levels of LDL cholesterol.
Benefits
Repatha has been shown to significantly lower LDL cholesterol levels in people with high cholesterol. The medication has been shown to reduce LDL cholesterol levels by up to 60% in clinical trials. Repatha has also been shown to reduce the risk of heart attack, stroke, and other cardiovascular problems in people with high cholesterol. This medication is usually prescribed in addition to a healthy diet and exercise regime.
Side Effects
Like all medications, Repatha has the potential to cause side effects. Some of the most common side effects of Repatha include:
- Injection site reactions, such as redness, swelling, or soreness
- Flu-like symptoms, such as fever, chills, and body aches
- Nausea
- Back pain
- Headache
Rare but serious side effects of Repatha include:
- Allergic reactions, such as hives, swelling, or difficulty breathing
- Upper respiratory tract infections, such as bronchitis or pneumonia
- Liver problems, such as elevated liver enzymes
- Neurological problems, such as memory loss, confusion, or seizures
If you experience any of these side effects while taking Repatha, you should immediately contact your doctor.
Warnings
Repatha is not recommended for people with a history of allergic reactions to the medication or any of its components. Before taking Repatha, you should tell your doctor if you:
- Are pregnant or planning to become pregnant
- Are breastfeeding
- Have liver or kidney problems
- Have a history of neurological problems, such as seizures or memory loss
- Are taking any other medications, including over-the-counter medications, supplements, or herbal remedies
Repatha may interact with other medications, including blood thinners and immunosuppressants. You should talk to your doctor about any medications you are taking before starting Repatha.
You should also discuss the risks and benefits of Repatha with your doctor if you have a history of muscle problems, such as myalgia or rhabdomyolysis. Repatha has been associated with an increased risk of muscle problems in some people, although this risk is considered to be low.
FAQs
Repatha is usually administered once every two weeks or once every four weeks by subcutaneous injection. Your doctor will determine the appropriate dosing schedule for you.
Repatha can lower LDL cholesterol levels within a few weeks of starting treatment.
Repatha has not been approved for use in children.
If you miss a dose of Repatha, you should take it as soon as you remember. If it is close to the time for your next dose, you should skip the missed dose and continue with your regular dosing schedule. Do not take two doses of Repatha at the same time.
Most insurance plans cover Repatha, although the specific coverage and cost may vary depending on your insurance provider. You should talk to your doctor or pharmacist about the cost of Repatha and whether your insurance plan covers it.
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