Trelegy: Uses – Side Effects – Warnings

Trelegy is a prescription medicine that is used to treat chronic obstructive pulmonary disease (COPD) in adults. It contains three active ingredients – fluticasone furoate, umeclidinium, and vilanterol – combined in a single inhaler. Trelegy is a long-acting inhaler that needs to be taken only once daily.


Trelegy is intended for the long-term management of COPD. COPD is a chronic lung disease that causes breathing difficulties and frequent coughing. It includes two main conditions: chronic bronchitis and emphysema. Trelegy eases the symptoms of COPD like shortness of breath, chronic coughing, and chest tightness.


Trelegy is a combination of three medicines that work together to provide a better treatment option for COPD patients. The benefits of Trelegy are:

  • Reduces the risk of COPD exacerbations (flare-ups) and hospitalizations
  • Improves lung function and reduces symptoms like shortness of breath and chest tightness
  • Increases exercise tolerance
  • Provides long-term relief with once-daily administration

Side Effects

Like any medicine, Trelegy can cause side effects in some people. Some common side effects of Trelegy include:

  • Headache
  • Infection in the upper respiratory tract
  • Throat irritation
  • Back pain
  • Cough
  • Diarrhea
  • Nausea
  • Viral infection

If these side effects persist or worsen, inform your doctor.

Some rare but serious side effects of Trelegy include:

  • Allergic reaction, including rash, hives, itching, and swelling of the face, tongue, or throat
  • Heart-related side effects, such as chest pain, rapid heartbeat, and high blood pressure
  • Worsening of breathing problems, including shortness of breath and wheezing
  • Bacterial pneumonia


Before starting Trelegy, inform your doctor if you have any medical conditions or allergies. Trelegy may not be safe for people with certain conditions, including:

  • Allergic to fluticasone, umeclidinium, or vilanterol
  • Under 18 years of age
  • Pregnant or breastfeeding
  • Heart disease or high blood pressure
  • Diabetes
  • Thyroid disorder
  • Seizures
  • Osteoporosis
  • Glaucoma or cataracts

Trelegy may interact with other medicines that you are taking. Inform your doctor about all the medicines, vitamins, and herbal supplements you are currently taking.


  1. What should I do if I miss a dose?

    A: If you miss a dose of Trelegy, take it as soon as you remember. But if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  2. Can I use Trelegy for sudden breathing problems?

    A: No, Trelegy is not meant for sudden breathing problems. It is a long-term medication that needs to be taken regularly to manage COPD symptoms.

  3. How long does it take for Trelegy to work?

    A: Trelegy starts working within a few days of starting treatment. However, it may take several weeks for you to feel the full benefit of the medicine.

  4. Can Trelegy cause weight gain?

    A: Weight gain is not a common side effect of Trelegy. However, if you experience unexplained weight gain while taking Trelegy, consult your doctor.

  5. Can Trelegy be used for asthma?

    A: No, Trelegy is not indicated for the treatment of asthma. It is specifically designed for the management of COPD. If you have asthma, consult your doctor for appropriate treatment.

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