Duobrii: Uses – Side Effects – Warnings

Duobrii is a combination medication consisting of halobetasol propionate, a potent corticosteroid, and tazarotene, a vitamin-A derived retinoid. This medication is used to treat plaque psoriasis in adults. Duobrii helps to reduce the redness, scaling, and itching associated with psoriasis. It is available in the form of a topical lotion, and it should be used as directed by a physician.


Duobrii is used to treat plaque psoriasis in adults. Plaque psoriasis is an autoimmune skin condition that causes red, scaly patches on the skin. These patches can be itchy and painful. Duobrii works by reducing the inflammation and scaling of the skin associated with psoriasis. This medication is only available with a prescription from a healthcare provider.


Duobrii provides relief from the symptoms of plaque psoriasis. Some of the benefits of using Duobrii include:

1. Reduction in redness and scaling of the skin
2. Decreased itchiness and discomfort
3. Improvement in the appearance of psoriasis plaques
4. Convenient topical application

Duobrii is a combination of two medications that work together to provide relief from the symptoms of psoriasis. Halobetasol propionate is a strong corticosteroid that reduces inflammation and swelling, while tazarotene is a vitamin-A derived retinoid that promotes healthy skin growth and reduces scaling and redness.

Side Effects

Common side effects of Duobrii include:

1. Burning or stinging sensation at the application site
2. Dryness or flaking of the skin
3. Itching or irritation
4. Skin discoloration
5. Worsening of psoriasis symptoms

Serious side effects of Duobrii are rare but can occur. Seek medical attention immediately if you experience:

1. Allergic reaction (hives, difficulty breathing, swelling of the face, lips, tongue, or throat)
2. Vision changes
3. Severe skin irritation or blistering at the application site
4. Elevated blood pressure


1. Do not use Duobrii if you are allergic to either halobetasol propionate or tazarotene.
2. Duobrii is for topical use only and should not be ingested or used on the face, underarms, or groin area.
3. Use Duobrii exactly as prescribed by your healthcare provider. Do not use more or less than recommended.
4. Do not use Duobrii if you have skin infections, open wounds, or cuts in the application area.
5. Do not cover the application area with a bandage, dressing, or other covering.
6. Duobrii may make your skin more sensitive to sunlight. Avoid exposure to sunlight or tanning beds while using this medication.
7. Use caution when applying Duobrii to sensitive areas such as the neck or around the eyes.


How long does it take for Duobrii to work?

Results vary based on the severity of the psoriasis and individual response to the medication. Improvement can be seen within 2-4 weeks of starting treatment.

Can Duobrii be used during pregnancy or breastfeeding?

This medication is classified as pregnancy category C, meaning it may be harmful to a developing fetus. Duobrii should only be used during pregnancy or breastfeeding if the benefits outweigh the risks.

Can Duobrii be used on children?

This medication has not been tested in children under the age of 18, and therefore is not recommended for use in children.

How long should I use Duobrii?

Use Duobrii as directed by your healthcare provider. Do not use for longer than necessary or more frequently than recommended.

Can Duobrii be used with other psoriasis medications?

It is important to discuss all medications, including psoriasis medications, with your healthcare provider to avoid any potential interactions.

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